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好运彩票网站电话

Chemical synthesis needs to evolve and adapt to the challenges of the future, and free itself from the restraints of laborious and time-consuming processes. New technologies must strive to provide safe, effective and productivity enhancing solutions. Our new automated capsule based synthesiser addresses all these issues and more!

The Synple 2 is the first easy to use automated synthesis device that increases your daliy productivity without any hassles.
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The small and compact capsule-based synthesizer for the generation of research products, works in an analogous manner to a capsule coffee maker. Simply add the starting material to be transformed and a commercially available, single-use, disposable reagent capsule and with a single touch of a button, the product is generated, isolated and purified!
 
Following the generation of the desired product, an automated washing sequence allows the machine to be used directly by another user without risk of contamination. With all the chemicals and solvents required for the transformation, as well as the waste generated, the risk of user exposure is drastically reduced. Thus this technology offers not only time-saving, productivity, and efficiency benefits, but it offers a far safer process than the respective traditional synthetic procedure.
The 3 in 1 solution offers an unprecedented combination of hardware, software and an optimized chemical process. Use of the automated synthesizer, in conjunction with the specialised capsules, offers the opportunity to break free of the limitations imposed by traditional synthesis, and the benefits of a safe, time-efficient, cost effective, plug and play synthetic procedure.

好运彩票网站电话

好运彩票网站电话

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红双喜彩票网址  長江商報消息●長江商報記者江楚雅  “2019年完成200億元銷售額,三年內做到500億元,五年做到1000億元  數字支付與商家服務、數字金融科技服務、創新業務及其他,構成營收的三大板塊,2020年1-6月,這3大項的占比分別為35.86%、63.39%和0.75%,其中數字金融科技服務費的占比最高

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  • Reagent cartridges are available for eight distinct reaction classes, with more than different 40 reagents.
  • Each cartridge contains a scannable chip enabling the the standardized reaction sequence to be loaded without any further programming.
  • Key reaction parameters (time, temperature, etc.) can be easily modified.
New reaction application are frequently released to expand the number of reaction types you can run on the same Synple instrument.

Click on the cartridge to see what reagents are contained in them and how the reactions work. A detailed set of application notes is available for each type of cartridge
 
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好运彩票网站电话

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好运彩票网站电话

好运彩票网站电话

好运彩票网站电话

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好运彩票网站电话

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好运彩票网站电话

Much less working time is required to generate new molecules. The synthesizer will only take 5-10 minutes to set up and will run completely autonomously. This offers the potential to increase the productivity of every synthetic chemist, whatever level of skill and experience.
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好运彩票网站电话

宏发彩票平台全球最聰明的錢嗅到了螞蟻科技價值的味道,這是螞蟻最大IPO紀錄誕生的根本公司主要產品為AI/ICT運營管理、游戲、物聯網/通訊、創新服務

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好运彩票网站电话

湖北福利彩票app安卓  數字支付與商家服務、數字金融科技服務、創新業務及其他,構成營收的三大板塊,2020年1-6月,這3大項的占比分別為35.86%、63.39%和0.75%,其中數字金融科技服務費的占比最高  記者注意到,上述地址對應的是寫字樓“中欣銀寶通大廈”,該地塊位于北京城區核心區域,毗鄰前門

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河北体育彩票11选五官网2020年1-9月,中交地產實現營業收入80.27億元,同比增長74.82%;實現歸屬于上市股東的凈利潤2.86億元,同比增長75.09%  螞蟻所處的時代,是數字經濟時代的大勢

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好运彩票网站电话

With only 25 x 35 cm footprint, the synthesizer uses only a minimum amount of space and fits in every laboratory.
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好运彩票网站电话

鸿发彩票平台别让我买  根據長江汽車2016年時公布的計劃,該公司基本上1-2年就會推出一款乘用車新車型,包括C級、D級車型記者在現場走訪了解到,事故大概發生在6點半左右,當時環衛工的頭部被夾在車頭和車廂之間的位置,整個身體露在外面

好运彩票网站电话

好运彩票网站电话

Snyple Chem was founded in 2016 as a Spin-off from ETH Zürich. Our mission is to provide easy to use, safe, efficiency-enhancing solutions that represent the future of organic synthesis. 
 

好运彩票网站电话

Now, alongside the Synple 1 and 2, we have our latest addition - the Synple Unity, a flexible parallel synthesiser.
 

好运彩票网站电话

No, the cartridges come ready filled with all the reagents and materials required for the reaction, work-up and purification. We can, however, provide custom cartridges for users under certain circumstances.
 

好运彩票网站电话

The machine itself is tolerant of almost all solvents. The limitation are only related to what is tolerated in terms of the chemistry by each reaction class. More information can be found in our application notes.
 

好运彩票网站电话

In many cases, co-solvents can be added to help solubiulise poorly soluble starting materials. 
 

好运彩票网站电话

We provide a scope for each reaction that indicates what is fast reacting and slow reacting. For slower reacting materials we recommend increasing the default reaction time. 

好运彩票网站电话

With the Synple 1 and Synple 2, only one reaction can be run at a time. The Synple Unity system allows you to build a parallel synthesis system to suit your own needs.
 

好运彩票网站电话

The machine requires very little maintenance and most of the components, e.g. the lines, connections, vial, are all standard. We are also able to offer service and maintenance contracts.
 

好运彩票网站电话

Yes! Our Synple 1 machines have been installed with customers since May 2018 and our new Synple 2s have been in use since October 2019.
 

好运彩票网站电话

At the moment we sell directly across Europe and the UK. We can also sell direct in the US or alternatively use a distributor. In addition, we are in discussions with several distributors across Asia.
 

好运彩票网站电话

The average lead time for the machine is four weeks. Cartridges can be delivered within the week.

好运彩票网站电话

This depends on the reaction class and what is tolerated by each particular reaction. In many cases co-solvents can be used to help solubilise the starting material.
 

好运彩票网站电话

Each method has been pre-optimised to give the best yield and purity across a broad substrate scope. If optimisation is required then we would recommend skipping the purification step and checking the product at the end of the run. If it has not gone to completion, the reaction can be run again.
 

好运彩票网站电话

This is something we are actively exploring.

好运彩票网站电话

This is dependant on the reaction class. Each run time includes the reaction, work-up and purification time.
A detailed overview can be found in the ressource section.

好运彩票网站电话

We are working with the Synple instrument in our laboratory for several months now
The first reaction tested was the one using SnAP reagents. The interest of this reaction developed by Professor BODE to form original saturated heterocycles was presented to us at a medicinal chemistry symposium a few years ago.
We then purchased the corresponding SnAP reagents sold by Aldrich and tested them under conventional laboratory conditions with original aldehydes and ketones. Although the results were satisfactory, the perspective of using potentially toxic products such as tin derivatives was not very encouraging. This very simple to use synthesizer has not only avoided handling these reagents but also improved the efficiency of the reaction by leading to often clean products with good yields.
Applied to reductive amination reactions, the same technology has led to variable results, more or less satisfactory depending on the type of amines used (salified, primary or secondary).
Two very convincing tests were also carried out on the formation of PROTACs from aldehyde and appropriate pre-filled cartridge.
Ease of use, reproducibility of experiments and non-exposure to toxic chemical substances are the major assets of this new automated synthesizers, which should be developed in particular to support scale-up.

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The machine is really very easy to use. This technology was not really part of our automation strategy but we have been surprised how quickly it was adopted.
 
We have had the Synple instrument in our labs for several months now. We like the instrument and it works perfectly well. We have found that anyone can get good results with the SnAP cartridges without first having to learn the insights of SnAP through painful failures. The same chemistry on the same scale was far better on the instrument than it was in the flask.
The reductive alkylation of secondary amines was successfully achieved using paraformaldehyde and small amine fragments, resulting in water soluble products. The instrument gave the product in good quantity and initial quality. Although the final products did need some further purification, our chemists struggled to reach the same level of quantity and purity when the reaction was performed in a flask.
In summary, the instrument really makes life easier and, especially if there were a way to scale up the reactions in a similarly easy way, then I wouldn’t want anyone in my organization to perform the SnAP and reductive alkylation reactions in the traditional way. Just adding the reagents and then pressing the button is so much easier and reproducible.
The machine is very easy to use and took no more than 10-15 minutes for us to do the whole process. Everyone who has used it thinks that it does increase their productivity. I personally made compounds that I would otherwise not have had the time to make
We consider the instrument very valuable to quickly make a set of PROTACs from scratch.

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